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Introduction

Introduction

Used to prevent or slow progression of atherosclerosis to reduce the risk of coronary artery disease and prolong life

Cholesterol

Advantages

Serves as a component of cell membranes and intracellular organelle membranes

Is involved in the synthesis of certain hormones including estrogen, progesterone, testosterone, adrenal corticosteroids

Needed for the synthesis of bile salts which are needed for digestion and absorption of fats.

Lipoproteins

Lipoproteins of importance

HDL (high density lipoprotein)

“Good cholesterol”

Contain cholesterol

Account for 20-30% of cholesterol in the blood

Some contain Apo A-I and Apo A-II

Apo A-I is cardioprotective

Transports cholesterol from the peripheral tissues back to the liver – promotes cholesterol removal

Antiatherogenic

فهرست مطالب و اسلایدها

Introduction

Cholesterol

Advantages

Origin

Lipoproteins

Lipoproteins of importance

LDL (low density lipoprotein)

HDL (high density lipoprotein)

Non-Pharmacological Therapy – 1st line tx

Niacin: chmeistry

Antilipemic agents

Niacin

MOA

Niacin – Adverse effects

Flushing

Fibrates (gemfibrozil, fenofibrate, clofibrate, bezafibrate)

Bile Acid-Binding Resins :chemistry

HMG COA Reductase Inhibitors

(“statins”)

Ezetimibe:chemistry

Ezetimibe

Inhibitors of Cholesteryl Ester Transfer Protein